Allerson, Charles: search on Z-Library

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1

Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA

Allerson, Charles R., Sioufi, Namir, Jarres, Russell, Prakash, Thazha P., Naik, Nishant, Berdeja, Andres, Wanders, Lisa, Griffey, Richard H., Swayze, Eric E., Bhat, Balkrishen

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 149 KB

english, 2005

2

Synthesis and Biophysical Evaluation of 2′,4′-Constrained 2′ O -Methoxyethyl and 2′,4′-Constrained 2′ O -Ethyl Nucleic Acid Analogues

Seth, Punit P., Vasquez, Guillermo, Allerson, Charles A., Berdeja, Andres, Gaus, Hans, Kinberger, Garth A., Prakash, Thazha P., Migawa, Michael T., Bhat, Balkrishen, Swayze, Eric E.

Journal:

Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

3

Synthesis and biophysical characterization of R-6′-Me-α-l-LNA modified oligonucleotides

Punit P. Seth, Jinghua Yu, Charles R. Allerson, Andres Berdeja, Eric E. Swayze

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 519 KB

english, 2011

4

Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease

Lee, Edmund C., Valencia, Tania, Allerson, Charles, Schairer, Annelie, Flaten, Andrea, Yheskel, Matanel, Kersjes, Kara, Li, Jian, Gatto, Sole, Takhar, Mandeep, Lockton, Steven, Pavlicek, Adam, Kim, Mi

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 4.01 MB

english, 2019

5

Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

Egli, Martin, Pallan, Pradeep S., Allerson, Charles R., Prakash, Thazha P., Berdeja, Andres, Yu, Jinghua, Lee, Sam, Watt, Andrew, Gaus, Hans, Bhat, Balkrishen, Swayze, Eric E., Seth, Punit P.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 2.96 MB

english, 2011

6

Regioselective Syntheses of 7-Nitro-7-deazapurine Nucleosides and Nucleotides for Efficient PCR Incorporation

Kawate, Tomohiko, Allerson, Charles R., Wolfe, Jia Liu

Journal:

Organic Letters

Year:

2005

Language:

english

File:

PDF, 75 KB

english, 2005

7

Synthesis and Application of Nitro-Substituted Nucleosides and Nucleotides

Kawate, Tomohiko, Wang, Bing, Allerson, Charles, Wolfe, Jia

Journal:

Year:

2006

Language:

english

File:

PDF, 367 KB

english, 2006

8

Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

Seth, Punit P, Jazayeri, Ali, Yu, Jeff, Allerson, Charles R, Bhat, Balkrishen, Swayze, Eric E

Journal:

Molecular Therapy — Nucleic Acids

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

9

Positional Effect of Chemical Modifications on Short Interference RNA Activity in Mammalian Cells

Prakash, Thazha P., Allerson, Charles R., Dande, Prasad, Vickers, Timothy A., Sioufi, Namir, Jarres, Russell, Baker, Brenda F., Swayze, Eric E., Griffey, Richard H., Bhat, Balkrishen

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 794 KB

english, 2005

10

Structure and nuclease resistance of 2′,4′-constrained 2′-O-methoxyethyl (cMOE) and 2′-O-ethyl (cEt) modified DNAs

Pallan, Pradeep S., Allerson, Charles R., Berdeja, Andres, Seth, Punit P., Swayze, Eric E., Prakash, Thazha P., Egli, Martin

Journal:

Chemical Communications

Year:

2012

Language:

english

File:

PDF, 1.50 MB

english, 2012

11

Structural requirements for hybridization at the 5′-position are different in α-l-LNA as compared to β-d-LNA

Punit P. Seth, Charles R. Allerson, Michael E. Østergaard, Eric E. Swayze

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 429 KB

english, 2012

12

A Chemical Method for Site-Specific Modification of RNA: The Convertible Nucleoside Approach

Allerson, Charles R., Chen, Swaine L., Verdine, Gregory L.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 384 KB

english, 1997

13

Synthesis and biophysical evaluation of 3′-Me-α-l-LNA – Substitution in the minor groove of α-l-LNA duplexes

Punit P. Seth, Charles A. Allerson, Michael E. Østergaard, Eric E. Swayze

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 439 KB

english, 2011

14

Synthesis and biochemical evaluation of RNA containing an intrahelical disulfide crosslink

Charles R. Allerson, Gregory I. Verdine

Journal:

Chemistry & Biology

Year:

1995

Language:

english

File:

PDF, 1.78 MB

english, 1995

15

Antisense Oligonucleotides Containing Conformationally Constrained 2′,4′-( N -Methoxy)aminomethylene and 2′,4′-Aminooxymethylene and 2′- O ,4′- C -Aminomethylene Bridged Nucleoside Analogues Show Improved Potency in Animal Models

Prakash, Thazha P., Siwkowski, Andrew, Allerson, Charles R., Migawa, Michael T., Lee, Sam, Gaus, Hans J., Black, Chris, Seth, Punit P., Swayze, Eric E., Bhat, Balkrishen

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.75 MB

english, 2010

16

Insights from Crystal Structures into the Opposite Effects on RNA Affinity Caused by the S - and R -6′-Methyl Backbone Modifications of 3′-Fluoro Hexitol Nucleic Acid

Pallan, Pradeep S., Yu, Jinghua, Allerson, Charles R., Swayze, Eric E., Seth, Punit, Egli, Martin

Journal:

Year:

2012

Language:

english

File:

PDF, 1.05 MB

english, 2012

17

An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

Seth, Punit P., Allerson, Charles R., Berdeja, Andres, Siwkowski, Andrew, Pallan, Pradeep S., Gaus, Hans, Prakash, Thazha P., Watt, Andrew T., Egli, Martin, Swayze, Eric E.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

18

Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals

Seth, Punit P., Siwkowski, Andrew, Allerson, Charles R., Vasquez, Guillermo, Lee, Sam, Prakash, Thazha P., Wancewicz, Edward V., Witchell, Donna, Swayze, Eric E.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 454 KB

english, 2009

19

Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2′-Fluoro RNA

Seth, Punit P., Yu, Jinghua, Jazayeri, Ali, Pallan, Pradeep S., Allerson, Charles R, Østergaard, Michael E., Liu, Fengwu, Herdewijn, Piet, Egli, Martin, Swayze, Eric E.

Journal:

Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 2.06 MB

english, 2012

20

Configuration of the 5′-Methyl Group Modulates the Biophysical and Biological Properties of Locked Nucleic Acid (LNA) Oligonucleotides

Seth, Punit P., Allerson, Charles R., Siwkowski, Andrew, Vasquez, Guillermo, Berdeja, Andres, Migawa, Michael T., Gaus, Hans, Prakash, Thazha P., Bhat, Balkrishen, Swayze, Eric E.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.52 MB

english, 2010

21

Replacing the 2′-oxygen with an exocyclic methylene group reverses the stabilization effects of α-l-LNA

Punit P. Seth, Charles R. Allerson, Andres Berdeja, Eric E. Swayze

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 422 KB

english, 2011

22

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

Eldrup, Anne B., Allerson, Charles R., Bennett, C. Frank, Bera, Sanjib, Bhat, Balkrishen, Bhat, Neelima, Bosserman, Michele R., Brooks, Jennifer, Burlein, Christine, Carroll, Steven S., Cook, P. Dan,

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 192 KB

english, 2004

23

Iron-dependent regulation of the divalent metal ion transporter

Hiromi Gunshin, Charles R. Allerson, Maria Polycarpou-Schwarz, Andreas Rofts, Jack T. Rogers, Fumio Kishi, Matthias W. Hentze, Tracey A. Rouault, Nancy C. Andrews, Matthias A. Hediger

Journal:

Year:

2001

Language:

english

File:

PDF, 302 KB

english, 2001

24

Discovery and preclinical evaluation of anti-miR-17 oligonucleotide RGLS4326 for the treatment of polycystic kidney disease

Lee, Edmund C., Valencia, Tania, Allerson, Charles, Schairer, Annelie, Flaten, Andrea, Yheskel, Matanel, Kersjes, Kara, Li, Jian, Gatto, Sole, Takhar, Mandeep, Lockton, Steven, Pavlicek, Adam, Kim, Mi

Journal:

Nature Communications

Year:

2019

File:

PDF, 4.01 MB

2019

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